Florencia 13 became well established in South Los Angeles by the 1930s. The gang was named after Florence Avenue.
The FBI began targeting Florencia 13 gang members for their roles in attacking African-Americans. According to the FBI, "The jury heard testimony that F13 members indiscriminately targeted African-Americans who were seen in their neighborhoods."
At certain times, Florencia 13 leaders ordered killings of the East Coast Crip gang,